Sesshomaru is one of the most iconic characters in the anime world with his long silver hair and piercing blue eyes. He is the half-demon brother of the main protagonist, Inuyasha, and is known for his cold and calculating persona. Despite being an antagonist in the beginning, Sesshomaru undergoes a significant character development throughout the series, making him a complex and intriguing villain.1. Sesshomaru (Inuyasha)
Shogo Makishima may not have blue hair, but his piercing blue eyes and manipulative nature make him a standout antagonist in the world of anime. He is a mastermind behind several crimes in the dystopian world of Psycho-Pass, and his ideology of rejecting a controlled society makes him a formidable opponent for the main characters. His intelligence and charm make him a fan-favorite villain, despite his heinous actions.2. Shogo Makishima (Psycho-Pass)
When it comes to Dio Brando, one word comes to mind – iconic. His signature blonde hair with a blue tint and his menacing presence have made him a staple in the world of anime villains. He is known for his ambition and ruthlessness, as well as his infamous catchphrase, "Muda, muda, muda!" His battles with the Joestar family have become some of the most memorable moments in the Jojo's Bizarre Adventure franchise.3. Dio Brando (Jojo's Bizarre Adventure)
Frieza may be a fan-favorite in the Dragon Ball Z series, but there's no denying that he is one of the most feared and powerful antagonists. With his signature purple and blue skin, along with his iconic golden form, Frieza has become an iconic villain in the anime world. His desire for power and ruthless actions have made him a formidable opponent for Goku and his friends.4. Frieza (Dragon Ball Z)
Aizen Sosuke is the main antagonist in the Bleach series, and his blue hair is just one of the many things that make him stand out. He is a master manipulator, constantly pulling the strings behind the scenes to achieve his ultimate goal of becoming a god-like being. With his calm and collected demeanor, Aizen Sosuke is a villain that will leave a lasting impression on viewers.5. Aizen Sosuke (Bleach)
When it comes to Hisoka, his blue hair is just a small part of what makes him such a captivating antagonist in the Hunter x Hunter series. His unpredictable nature and obsession with finding strong opponents make him a formidable foe for the main characters. Despite his villainous actions, Hisoka has become a fan-favorite due to his unique personality and fighting style.6. Hisoka (Hunter x Hunter)
Shinsuke Takasugi may not have the traditional blue hair, but his blue highlights and intense glare make him a standout antagonist in the Gintama series. He is a former ally turned enemy of the main character, Gintoki, and his desire for revenge against the government makes him a complex and intriguing villain. His swordsmanship and cunning tactics make him a formidable opponent in battle.7. Shinsuke Takasugi (Gintama)
Esdeath is a powerful and sadistic antagonist in the Akame ga Kill series, with her signature blue hair and piercing red eyes. She is a high-ranking member of the Empire and is known for her immense strength, making her a formidable opponent for the main characters. Her twisted sense of justice and brutal methods make her a memorable and somewhat sympathetic villain.8. Esdeath (Akame ga Kill)
Meruem may not have blue hair, but his blue eyes and intimidating presence make him a standout antagonist in the Hunter x Hunter series. He is the King of the Chimera Ants, a species known for their incredible strength and intelligence. As the main antagonist of the Chimera Ant arc, Meruem proves to be a formidable foe for the main characters, with his strategic thinking and immense power.9. Meruem (Hunter x Hunter)
Shou Tucker may not have the typical blue hair of an anime antagonist, but his actions make him one of the most despised villains in the Fullmetal Alchemist series. He is a brilliant alchemist who is willing to sacrifice his own family for the sake of his research. His betrayal and cruel experiments make him a detestable character, earning him the nickname "Sewing-Life Alchemist."10. Shou Tucker (Fullmetal Alchemist)